The dialysis business: Stakes in kidneys | The Economist

Stakes in kidneys

The battle over one of medicine’s fastest-growing and least loved markets

Apr 15th 2010 | BERLIN | From The Economist print edition

DIALYSIS—the use of machinery to make up for malfunctioning kidneys—is among medicine’s least loved treatments, both to endure and to administer. Patients have to be hooked to machines for hours at a time every few days. Those providing care often find it difficult, too: as many as a fifth of their patients die each year, many of them after choosing to stop their treatment. But it is also a fast-growing and lucrative market, and one that provides valuable lessons about making health care affordable.

Dialysis is dominated by an oligopoly. Fresenius Medical Care, the dialysis business of Germany’s Fresenius, makes more than half of the dialysis machines sold in the world, followed by Gambro, a Swedish firm. Ulf Mark Schneider, the chief executive of Fresenius, attributes his company’s success to the fact that it plays to traditional German strengths. “A dialysis machine has the same number of parts as a car,” he says. “Making one brings together electronics and mechanical engineering, which Germany is good at.”

The real money, however, is in running dialysis clinics and administering drugs, which account for 80% of the cost of dialysis. The two biggest operators of dialysis clinics are Fresenius and DaVita, which bought Gambro’s American clinics in 2004. Each of them runs almost a third of America’s dialysis clinics.

Some 2m people receive regular dialysis to clean their blood of impurities that build up as a result of kidney failure. About a quarter of them are in America, which has one of the highest rates of dialysis in the world. This is less because Americans are especially unhealthy (although high rates of obesity and diabetes do play a role) and more because American health policy is to provide dialysis to anyone who needs it, regardless of their ability to pay or their chances of surviving much more than a few months. It is also the world’s most lucrative dialysis market, with the government spending $24 billion a year, or $71,000 a year per patient, on dialysis, and private insurers paying yet more.

But the number of patients is growing fast all over the place (see chart), as is the cost of treatment. In Britain around 3% of health spending is devoted to treating kidney failure, a proportion that has increased by about 50% in recent years. Globally, the number of patients on dialysis is likely to double over the coming decade. Most of them will be in developing countries, where numbers are growing by 10% or more a year. Worsening diets are playing a part but so are rising incomes, as a result of which health systems treat people who would previously have been left to die.

With spending rising rapidly, attention is now focused on to trying to control costs. Fresenius’s experience offers two lessons. First, combining the manufacture of machines with the running of clinics has helped it dominate both markets. “The thing that other people in the industry admire about Fresenius is this one-stop shopping model,” says Stephan Danner of Roland Berger, a consulting firm. By the same token, Gambro is the preferred supplier for DaVita’s clinics. Second, Fresenius is ruthless about spending. Mr Schneider, who often flies economy on business trips, is outspoken in his criticism of the pharmaceutical industry’s “corptocracies”, which have high overheads that need to be supported by profit margins of as much as 80% on expensive blockbuster drugs.

Fresenius stands to become a big beneficiary as America’s health-care reforms take on some of the more bloated parts of the business. At present American dialysis clinics are paid on a “cost-plus” basis for the drugs they use. That, naturally, has encouraged them to use lots of expensive ones, which now account for almost a quarter of the total cost of treatment. Analysts at Bernstein, a research firm, note that American clinics used to favour an injected drug costing $4,100 a year over an identical oral one which was introduced to the market at a cost of $450 a year. After languishing unused, the oral drug now costs more than the injected one. “There is negative price elasticity here: the higher the price, the more competitive the product,” Bernstein’s analysts observe.

The reforms will introduce a “bundled price”, whereby clinics receive a set rate for providing treatment. Analysts expect drug costs to fall by at least 10% soon after the change, as clinics use fewer or cheaper drugs. A huge share of the savings will go straight to Fresenius’s bottom line.

nalozbena ideja?

Optimism Bias : The Frontal Cortex

AR in communications

---------- Forwarded message ----------
From: Emerging Communications Conference <mercy@ecommmedia.com>
Date: Fri, Apr 16, 2010 at 1:39 AM
Subject: 85 Talks/Switch to Invitation Only? (update #40)
To: darko.bodnaruk@gmail.com



Ecomm-madmimi-header2

The Emerging Communications Conference & Awards (eComm) is focused on 'What’s Next in Telecom, Mobile & Internet Communications™' (See http://eComm.ec for details)

Major event sponsors: Voxeo (Platinum), Skype (Platinum), Global IP Solutions (Gold), MetaSwitch (Gold), Ribbit (Gold)

Organizer Message

/.../

For example I'm totally jazzed about mobile augmented reality (AR) since it came of age at the end of 2009. So much so, the last day is dedicated to it and now it's stretching to a 12-hour day! It's going to be amazing and will be the first such commercial gathering. But in conversation with friends privately recently, it was evident that nobody (except Martin Geddes) understood the very likely tight coupling between AR and "communications". Such a tight coupling offers immense opportunities for a substantial percentage of companies in the mobile/telecom/Internet communications space. Let me tickle you. AR has been about overlaying the "online space" (e.g. media/information) onto the "offline" world (AKA "real world"), i.e. providing visual metadata. But significant opportunities are up for grabs (in the greenfield sense) by applying to communication services.

AR could be used as the interface to interact with the "digital space", in our case, communications services. For example you could "see" AR created photo frames in your living room of people you cherish. If one of these people calls you, their photo frame could flash and it's general color state could indicate how long ago since the last call from that person (if it's too long the photo frame can vanish). If you wish to create a conference call, you could "pick up" two such photo frames and knock them together. You can keep building out from there, e.g. have texts (SMS) displayed as sticky notes on the photo frame. Already magazines are beginning to embrace AR and it's a logical step to add in communication services, e.g. advertisements have an AR component such as an AR overlaid Twitter feed. This is all entirely possible. It will generate significant value and it's just the beginning. The question is where would your company fit in such a value chain? Whom should you partner with?

/.../

What to Do When There's Nothing to Do (Dylan Grice, SocGen)

(download)

tokrat za spremembo celo z nakupnimi priporočili...

Dylan-Grice-Selling-the-Yellow-Stuff

(download)

Hedge Fund Letters Blog - Increasing Hedge Fund Transparency

Are Americans Already Back to Their Old Ways?

via EconomPic by Jake on 3/29/10

Financial-Planning reports:

While 63% of Americans said they were concerned about the overall state of financial markets in 2009, just 45% said they were concerned in 2010.

Nervousness and fear about retirement dropped from 55% who were nervous or afraid last year to just 40% this year. American's concern about having enough money to retire has fallen from 56% in 2009 to 51% this year, the same as in early 2008, the study found.

“Americans appear more relaxed about retirement and are far less worried about their finances overall,” said Craig Hogan, Scottrade’s director of customer intelligence. “The number of people who reported being concerned about issues such as day-to-day expenses, education costs, paying off credit cards, and saving for big ticket purchases didn’t just decline – each category hit a four-year low.”

Which leads us to this morning's personal consumption and expenditure report. To the NY Times:

U.S. consumer spending rose as expected in February for a fifth straight month, while stagnant incomes pushed savings to their lowest level since October 2008, a government report showed on Monday.

The Commerce Department said spending increased 0.3 percent after rising by a slightly downwardly revised 0.4 percent in January. Consumer spending in January was previously reported to have increased 0.5 percent.

Source: BEA

Equity valuations: High valuations, low returns | The Economist

WHEN Robert Shiller produced his data in the 1990s showing that the cyclically-adjusted price-earnings ratio of US equities was ridiculously high, his logic was pooh-poohed. But the decade of the noughties was one of the worst ever for stockmarket returns.

Buy high, earn low is the rule. And the Shiller p/e is still high, in the top quintile of all the numbers (going back to 1880). According to Dylan Grice of Societe Generale, the subsequent 10-year returns to investors who bought equities in the top quintile were just 1.7% a year; buying when valuations were in the bottom quintile returned 11% annually.

post@darkobodnaruk.posterous.com

zelo relevantno za stratege...

March 25, 2010 - Update: Perfect Sector Rotation

Is the conventional wisdom that stocks of certain sectors outperform systematically during specific stages of the business cycle correct, and exploitable? In the December 2009 update of their draft paper entitled "Sector Rotation across the Business Cycle", Jeffrey Stangl, Ben Jacobsen and Nuttawat Visaltanachoti test the value of sector rotation by assuming that an investor anticipates U.S. business cycle stages perfectly and rotates sectors in accordance with conventional wisdom. The baseline business cycle consists of five stages across the peaks and troughs of economic activity declared by the National Bureau for Economic Research (NBER). The baseline conventional wisdom on sector rotation comes from Standard & Poor's Guide to Sector Investing. Using monthly industry returns, market returns and Treasury bill rates for 1948-2007 (10 business cycles), they find that:

  • The average length of U.S. business cycles since 1948 is 71 months, 61 months for expansions and 10 months for recessions (see the figure below).
  • On a nominal return basis, 33 of the 48 industries beat the market on average as expected during their optimal stages (see the table below). During late expansion, early recession and late recession (but not early and middle expansion), optimal industries in aggregate beat the market on average as expected.
  • With perfect business cycle foresight, conventional sector rotation outperforms the market by a gross 2.3% per year over the entire 60-year sample period. However:
    • This gross outperformance degrades to 1.9% and 1% (2.2% and 1.8%) per year when sector rotation is one and two months early (late), respectively.
    • Including trading frictions degrades the 2.3% annual outperformance to between 1.1% and 1.9% (depending on assumptions), statistically indistinguishable from zero.
    • Using the same perfect foresight to go to cash during early recessions and hold the market during all other business cycle stages outperforms the market by a gross 2.5% per year.
  • Moreover, contrary to conventional wisdom, industries optimal for a particular stage mostlyunderperform the market (28 out of 48 sectors) based on Sharpe ratio. Across various risk-adjustment methods, there is very little evidence of industry outperformance by stage in accordance with conventional wisdom.
  • Results are generally robust to alternate definitions of the business cycle and business cycle stages, subperiods, different risk adjustment approaches, different industry-business cycle relationships and different industry segmentations.
  • There are a few sectors with significant alphas during particular stages of the business cycle (performing well 60%–70% of the time), as follows:
    • Early expansion - none.
    • Middle expansion - Candy & Soda and Pharmaceuticals.
    • Late expansion - Mining and Tobacco Products.
    • Early recession - Shipping Containers, Food products, Utilities and Entertainment.
    • Late recession - Personal Services, Food Products and Tobacco Products.
  • With perfect business cycle foresight, this alternative sector rotation outperforms the market by a gross 7.3% per year (about 6.1% per year after trading frictions) over the entire 60-year sample period.

The following figure, taken from the paper, presents the baseline idealized business cycle divided into five stages. Expansions span trough to peak in three stages of equal length (Stages I-III). Recessions span peak to trough in two stages of equal length (Stages IV-V). As indicated, expansions are typically much longer than recessions. Since 1948, U.S. expansions (recessions) average 61 (10) months in length.

The following table, also from the paper, summarizes the baseline conventional wisdom (fromStandard & Poor's Guide to Sector Investing) on outperformance of sectors by stage of the business cycle.

Note that NBER can take as long as two years after a turning point to designate its date and that one business cycle can be very different from another.

In summary, realistic assumptions about business cycle predictability make it unlikely that an investor can outperform the broad stock market using a conventional sector rotation strategy. A more focused, unconventional sector rotation strategy might outperform.


http://www.cxoadvisory.com/blog/external/blog3-25-10/default.asp#